Autoimmune hepatitis and systemic sclerosis: a new overlap syndrome?
Identifieur interne : 001807 ( Main/Exploration ); précédent : 001806; suivant : 001808Autoimmune hepatitis and systemic sclerosis: a new overlap syndrome?
Auteurs : I. Marie ; H. Levesque ; J. L. Tranvouez ; A. Franc Ois ; G. Riachi [France] ; N. Cailleux ; H. CourtoisSource :
- Rheumatology [ 1462-0324 ] ; 2001-01.
English descriptors
Abstract
Objective. We report the cases of two patients with the complete CREST variant (calcinosis, Raynaud's phenomenon, oesophageal dysmotility, sclerodactyly, telangiectasia) of systemic sclerosis (SSc) who developed autoimmune hepatitis. Results. Our findings suggest that autoimmune hepatitis can be considered to be one of the liver manifestations associated with SSc. Our data also indicate that, because liver involvement may precede skin manifestations, evaluation for SSc is appropriate when autoimmune hepatitis is noted, and that the evaluation should include clinical examination, testing for antinuclear antibodies (especially for anticentromere antibodies) and nailfold capillaroscopy. Conclusions. From a practical point of view, our two cases emphasize that suspicion of autoimmune hepatitis in SSc patients presenting with cytolytic hepatitis will help to achieve both accurate diagnosis and optimal management.
Url:
DOI: 10.1093/rheumatology/40.1.102
Affiliations:
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Riachi</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Department of Gastroenterology, Centre Hospitalier Universitaire de Rouen, 76031 Rouen Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Cailleux, N" sort="Cailleux, N" uniqKey="Cailleux N" first="N." last="Cailleux">N. Cailleux</name></author><author><name sortKey="Courtois, H" sort="Courtois, H" uniqKey="Courtois H" first="H." last="Courtois">H. Courtois</name></author></analytic><monogr></monogr><series><title level="j">Rheumatology</title><title level="j" type="abbrev">Rheumatology</title><idno type="ISSN">1462-0324</idno><idno type="eISSN">1462-0332</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2001-01">2001-01</date><biblScope unit="volume">40</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="102">102</biblScope><biblScope unit="page" to="106">106</biblScope></imprint><idno type="ISSN">1462-0324</idno></series><idno type="istex">F1562CE0C5AA2E2F509B5BAF80D16C3859F44610</idno><idno type="DOI">10.1093/rheumatology/40.1.102</idno><idno type="PII">1460-2172</idno><idno type="local">400102</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1462-0324</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Autoimmune hepatitis.</term><term>CREST syndrome</term><term>Systemic sclerosis</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective. We report the cases of two patients with the complete CREST variant (calcinosis, Raynaud's phenomenon, oesophageal dysmotility, sclerodactyly, telangiectasia) of systemic sclerosis (SSc) who developed autoimmune hepatitis. Results. Our findings suggest that autoimmune hepatitis can be considered to be one of the liver manifestations associated with SSc. Our data also indicate that, because liver involvement may precede skin manifestations, evaluation for SSc is appropriate when autoimmune hepatitis is noted, and that the evaluation should include clinical examination, testing for antinuclear antibodies (especially for anticentromere antibodies) and nailfold capillaroscopy. Conclusions. From a practical point of view, our two cases emphasize that suspicion of autoimmune hepatitis in SSc patients presenting with cytolytic hepatitis will help to achieve both accurate diagnosis and optimal management.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Haute-Normandie</li><li>Région Normandie</li></region><settlement><li>Rouen</li></settlement></list><tree><noCountry><name sortKey="Cailleux, N" sort="Cailleux, N" uniqKey="Cailleux N" first="N." last="Cailleux">N. Cailleux</name><name sortKey="Courtois, H" sort="Courtois, H" uniqKey="Courtois H" first="H." last="Courtois">H. Courtois</name><name sortKey="Franc Ois, A" sort="Franc Ois, A" uniqKey="Franc Ois A" first="A." last="Franc Ois">A. Franc Ois</name><name sortKey="Levesque, H" sort="Levesque, H" uniqKey="Levesque H" first="H." last="Levesque">H. Levesque</name><name sortKey="Marie, I" sort="Marie, I" uniqKey="Marie I" first="I." last="Marie">I. Marie</name><name sortKey="Tranvouez, J L" sort="Tranvouez, J L" uniqKey="Tranvouez J" first="J. L." last="Tranvouez">J. L. Tranvouez</name></noCountry><country name="France"><region name="Région Normandie"><name sortKey="Riachi, G" sort="Riachi, G" uniqKey="Riachi G" first="G." last="Riachi">G. Riachi</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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